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Overview on Research

My research focuses on the preparation of amino-rich nano/micro/hydrogels with stimuli-responsiveness through the utilization of PAMAM dendrimers or amphiphilic reactive copolymers as building block by polymerization/crosslinking reactions using various methods, such as precipitation or miniemulsion polymerisation and microfluidics. These new microgels are employed to load multifunctional nanoparticles (e.g., Au, CuS NPs) for precision imaging and efficient photothermal therapy of tumors.

Research focus

• Synthesis of dendrimer-based nano/micro/hydrogels
• Synthesis of hybrid microgels loaded with CuS for photothermal therapies

Project

Sino-German Center for Research Promotion: Design of copper sulfide nanoparticle-loaded functional nanogels for photoacoustic imaging-guided tumor photothermal therapy

Publications

Li, X., Ouyang, Z., Li, H., Hu, C., Saha, P., Xing, L., Shi, X., Pich, A; Dendrimer-decorated nanogels: Efficient nanocarriers for biodistribution in vivo and chemotherapy of ovarian carcinoma. Bioactive materials, 6(10), 3244-3253; 2021.

Li, X., Li, H., Zhang, C., Pich, A., Xing, L., & Shi, X.; Intelligent nanogels with self-adaptive responsiveness for improved tumor drug delivery and augmented chemotherapy; Bioactive materials, 6(10), 3473-3484; 2021.

Li, X., Sun, H., Li, H., Hu, C., Luo, Y., Shi, X., Pich, A.; Multi‐Responsive Biodegradable Cationic Nanogels for Highly Efficient Treatment of Tumors; Advanced Functional Materials, 2100227; 2021.

Li, H., Li, X., Jain, P., Peng, H., Rahimi, K., Singh, S., Pich, A.; Dual-degradable biohybrid microgels by direct cross-linking of chitosan and dextran using azide–alkyne cycloaddition; Biomacromolecules, 21(12), 4933-4944; 2020.

Jia, L., Li, X., Liu, H., Xia, J., Shi, X., & Shen, M.; Ultrasound-enhanced precision tumor theranostics using cell membrane-coated and pH-responsive nanoclusters assembled from ultrasmall iron oxide nanoparticles; Nano Today, 36, 101022; 2021.